Pancreatic Cancer Cell Models

Next generation pancreatic cancer cell lines for precision therapeutics

Stable, authenticated, patient specific models for better decision making.

Next generation pancreatic cancer cell models overcome the limitations of traditional cell lines, transforming the quality and value of in vitro studies.

Pancreatic cancer is a challenging disease target. Tumors don’t often conform to standard definitions and may morph into other cancers in response to treatment.

Existing cell lines undermine efforts towards better, personalized, therapies for this complex, deadly disease. Poorly characterized and unrepresentative of the tumors of origin, the quality of existing cell lines is suspect, resulting in irreproducible studies. Existing cell lines only represent one patient. It is critical to analyze how a drug will respond in a range of patients with different characteristics. However, it is currently only possible to assess drug response in a wider population during clinical studies.

Our next generation pancreatic cancer cell lines, named Stew, Chocolate and Basket, represent a range of patients with different characteristics. They have a clear ancestral link to defined patient tumors.

Our cell models are more stable than traditional cell lines and maintain biomarker expression and cell heterogeneity for far longer. Using Cellaria’s pancreatic models, researchers can target specific patient cohorts with defined molecular targets and biomarkers in in vitro studies, enabling better decision making earlier in the process.  As a result, Stew, Chocolate and Basket reduce the time and cost of:

  • Identifying effective personalized therapies
  • Screening drugs for efficacy prior to clinical trials
  • Demonstrating reproducibility and cell line authentication

Stew patient-specific cell images

Basket patient-specific cell images

Basket patient-specific cell images

Chocolate patient-specific cell images

Chocolate patient-specific cell images

Benefits

Target a range of specific patient cohorts/subpopulations

Stew, Chocolate and Basket are derived from patients suffering from pancreatic adenocarcinoma, the most common form of pancreatic cancer. Each model has details of the gender, ethnicity, age, treatment history, co-morbidities and diagnosis of the patient. The patient specificity allows researchers to:

 

  • Test drugs against a range of patient subpopulations to evaluate efficacy prior to clinical trials.
  • Study the impact of co-morbidities, ethnographic and firmographic characteristics.
  • Advance personalized therapies for specific patient cohorts.
Use a cell line that truly represents the complexity of pancreatic cancer

In vitro studies are cost-effective relative to in vivo alternatives, minimizing the cost of disease research and drug development. However, many traditional cell lines no longer represent the heterogeneity of the original tumor due to factors such as genetic drift, selective overgrowth, and contamination.  In contrast, Stew, Chocolate and Basket are rigorously authenticated and consistently reflect the heterogeneity of the original tumor. Furthermore Cellaria’s models maintain a stable cell culture for the entire duration of more than 90% of experiments (c.f around 10 – 15% with traditional lines), representing a major gain in the reliability and productivity of in vitro studies.

Avoid the need for additional authentication with cell lines you can trust

Cellaria invests heavily in assay and cell line characterization including proteomic, genomic and biomarker analysis, gene expression and protein profiling. Each line comes with a Certificate of Analysis (COA) that describes growth characteristics, protocols for preserving biomarker expression and response to a minimum of three established drug therapies. All this vital information helps you to experiment productively and generate actionable data with high clinical relevance, from the outset.

Our research is ongoing, with continuing evaluation of the response of specific cell lines to different therapies and the criticality of different biomarkers. These efforts directly enhance the quality of decision-making in pre-clinical research and maximize the value of in vitro studies.

The results underpin the reliability of the cell line and form a COA that eliminates any requirements for the demonstration of authenticity.

  • Our cell models start with a primary patient specimen
  • Cellaria owns chain of custody for every sample
  • Models often validated for desired biomarkers

The problems associated with traditional cell lines are increasingly well-recognized:

‘… it is clear that reproduction of prior results may be problematic and investigators should limit interpretations to internally consistent data’ [Emily L. Deer, MD et al. Phenotype and Genotype of Pancreatic Cancer Cell Lines].

Cellaria offers breakthrough technology to tackle this issue and accelerate progress in clinical research.

Stew, Chocolate and Basket, Cellaria’s next generation pancreatic cancer cell models, deliver the reproducibility and clinical relevance required to improve R&D success for a difficult disease. They represent a major breakthrough relative to existing cell models with respect to:

  • Authenticated heritage
  • Patient specificity
  • Stability
  • Faithful heterogeneity and relevance
  • Accompanying documentation
  • Characterized response to established therapies

Wrapped with Cellaria’s scientific know-how, these cell lines directly mirror the established benefits of our existing portfolio for breast, colon, ovarian and lung cancer. They have significant potential to accelerate progress towards better cures for this deadly disease.

Long overdue precision medicine for pancreatic cancer

StewChocolateBasket

Is your patient cohort not represented above? Cellaria offers a suite of custom cancer cell model services to address the ever-changing research needs of the drug discovery pipeline.

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