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Jacket Lung Cell Model
The Jacket cell model originates from adenocarcinoma of the lung.
Product Family: Jacket Lung Cell Model
Disease Area: Cancer
Tissue Type: Lung
Clinical Diagnosis: Adenocarcinoma of the lung
| Disease Area: | Cancer |
| Tissue Type: | Lung |
| Clinical Diagnosis: | Adenocarcinoma of the lung |
| Age: | 70-74 |
| Sex: | Male |
| Ethnicity: | Caucasian |
| TNM Stage: | T2aN0MX |
| Grade: | IB |
| Co-indications: | N/A |
| Medications: | Ibuprofen |
| Country of Collection: | United States |
| Year of Origin: | 2013 |
Gene Mutations
| Gene | Alteration | Frequency (%) | Exon | Result |
| Androgen Receptor | F814V | 100 | 6 | Mutated, Presumed Pathogenic |
| KRAS | G12A | 100 | 2 | Mutated, Pathogenic |
| MSH6 | G477S | 32 | 4 | Mutated, Variant of Unknown Significance |
| MUTYH | V493M | 62 | 15 | Mutated, Variant of Unknown Significance |
| TP53 | S215G | 100 | 6 | Mutated, Presumed Pathogenic |
Jacket Growth Characteristics
The historical growth curve of Jacket demonstrates consistent growth and highlights the lack of cell crisis.
STR Profile
AMEL: X
CSF1PO: 11
D13S317: 13
D16S539: 12
D18S51: 17
D21S11: 28
D3S1358: 15
D5S818: 12
D7S820: 8, 10
D8S1179: 12
FGA: 23
Penta D: 9
Penta E: 7
TH01: 9
TPOX: 11
vWA: 14
Immunohistochemistry
Tumor sample diagnosis was confirmed by histology and immunohistochemical detection of tumor markers.
Lineage Markers
Immunofluorescence detection of lineage markers confirm epithelial phenotype using pan-keratin with DAPI overlay.
Tumorsphere Formation
Spontaneous formation of tumorspheres under low-attachment conditions.
N/A
Storage and Stability: Store frozen in liquid nitrogen.
Care and Use Instructions: See protocol for further details
Quality Control: All lots are tested for microbial and viral contamination, cell line cross-contamination, mycoplasma, and consistent growth capabilities. See Certificate of Analysis for further details.
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