Cellaria’s Recombinant Human Activin-A protein (also known as Inhibin A, encoded by INHBA gene) is a 26 kDa disulfide-linked homodimer of two Inhibin beta A chains, each containing 116 amino acid residues. Activin A homodimer has a major role in cell proliferation, differentiation, apoptosis, metabolism, homeostasis, immune response, wound repair, and endocrine function. Activin A is a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins, activating Alk4 and Alk7 receptor-like kinases, followed by Smad2/3 activation, formation of dimer complex with Smad4, nuclear translocation and subsequent activation or inhibition of nuclear factors-mediated gene transcription in cells.

Application note Title- Biological activity of Activin A

Product Info Sheet_ACTIVIN-A