Cancer Cell Models
Cellaria’s in vitro cancer cell models are derived directly from patient tumors to reflect the unique nature and complexity of each patient’s disease.
Now researchers can move away from traditional methodologies and forge a path to more personalized therapeutics.
WATCH A VIDEO to learn how are Cellaria’s cell models are different from the current cancer research options, such as, PDX and GEMMS.
Cellaria cell models vs. traditional cell lines:
- Developed with a breakthrough processOur holistic approach optimizes the entire culture environment including the growth substrate, culture medium, and oxygen tension.
- Unparalleled stabilityOur cell models are stable and show high concordance to the original tumor genotype through high passage as measured by SNP analysis.
- Backed by extensive dataOur models are traceable back to initial patient tumor and clinical conditions, simplifying the analysis of patient-specific responses.
- Stringent quality controlsOur intensive quality testing process protects your research with data on lot-specific cell growth, cell line authentication, and broad-spectrum sterility.
- Predictable growth ratesObtain the cells you need for high-throughput drug screening via optimized expansion protocols.
WATCH A VIDEO on Cellaria’s Cancer Cell Models.
Learn more about Cellaria’s cell models:
Cellaria’s key benchmarks for our cell models:
The following key benchmarks are the foundation of Cellaria’s cell models and represent key differentiators of our products in today’s market.
Offering sustained growth through innovation and optimization
The limited availability of representative tumor-derived cell lines constrains the scope of research in a very patient-specific disease. Some rarer sub-types of cancer have no models available at all.
Cellaria’s technology enables greater success in generating cell models from patient tumors, for both easy and difficult to grow cancer types. By supporting robust growth of multiple cell types within the tumor, our media and proprietary methods prevent cell death and large-scale cell selection within culture.
Documented quality and reproducibility
The lack of reproducible results is tied to a myriad of issues, including, wide-spread cell line cross-contamination, mycoplasma contamination, and variations in lot-to-lot performance.
Cellaria provides extensive quality testing to ensure the best performance in every lot of cells. In addition to testing for mycoplasma and all major forms of microbial and human viral contamination, we utilize STR fingerprinting to confirm the identity of your cells. We go the extra mile by providing expected growth performance that is confirmed to three passages after thaw, which can be achieved through our tailored protocols.
Informed cell model characterization that reflect clinical attributes
Our scientists work using the primary tumor as a reference, preserving the cancer cells within the tumor sample. Our model is accompanied by extensive clinical information and highlights of critical mutations and molecular markers. With Cellaria’s models, scientists can further translate research across varying patient populations.
Learn more about Cellaria’s cell models: Wood Breast Cell Model, Ferry Colon Cell Model, Jacket Lung Cell Model, and our two Ovarian Cell Models, Carousel (Endometrioid adenocarcinoma of the ovary) and Powder (Serous carcinoma of the ovary).
Cellaria offers two types of Media—Renaissance Essential Tumor MediumTM (RETM) and WIT Culture Media. RETM is used for the successful derivation of cancer cells and is specifically designed for extended in vitro propagation. It uses a simple, feeder-free protocol for a wide breadth of tumor types and produces cultures with less variability and more reproducible results. WIT Culture Media are optimized for the expansion of normal human mammary epithelial cells and human fallopian tissue. Completely defined and serum-free, this type of media has been used for a broad range of applications by scientists, including growth of lymphoma and mouse tumor tissue.
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